近十年来,对于肿瘤细胞增殖动力学(以下简称细胞动力学)的理论研究有迅速的发展,并与抗癌药物对瘤细胞代谢的研究结合起来指导临床实践,制定出合理的治疗方案,使疗效不断提高。1970年国外报道急性白血病治疗后生存五年以上的近200例,其中96例从诊断至今已生存8—20年。急性淋巴性白血病生存率逐年增加,从病人生存时间的统计资料可看出25年来治疗急性淋巴性白血病的疗效有显著提高(有一些病人已被认为治愈)。特别是根据白血病细胞动力学的知识设计抗癌药物综合应用以来,疗效更有提高。因此,临床医生在肿瘤化学治疗过 In the past ten years, the theoretical research on the proliferation kinetics of tumor cells (hereinafter referred to as cell dynamics) has developed rapidly, and it has been combined with studies on the metabolism of tumor cells by anticancer drugs to guide clinical practice and formulate a reasonable treatment plan. The curative effect continues to increase. In 1970, nearly 200 cases of acute leukemia survived after more than five years in foreign countries, of which 96 cases have survived for 8 to 20 years since diagnosis. The survival rate of acute lymphatic leukemia increases year by year. From the statistical data of patient survival time, it can be seen that the curative effect of treatment of acute lymphatic leukemia has improved significantly in 25 years (some patients have been considered to be cured). In particular, since the comprehensive application of anticancer drugs has been designed based on the knowledge of leukemia cell dynamics, the efficacy has been improved. Therefore, clinicians have treated cancer