恶性肿瘤是一种全身性、异质性疾病,针对全身治疗的化疗在肿瘤综合治疗中的重要作用受到人们重视,耐药是成功化疗的主要障碍,多药耐药(multidrug resistance,MDR)是引起化疗耐药的主要原因。研究表明引起MDR的机理较多,其中最主要的机理是多药耐药(mdr_1)基因过量表达,导致其产物P—糖蛋白(P—plycoprotein,PgP)在肿瘤细胞膜上含量增多, Malignancy is a systemic and heterogeneous disease. The importance of systemic chemotherapy in the treatment of cancer has drawn great attention. Resistance is the major obstacle to successful chemotherapy. Multidrug resistance (MDR) is a Resulting in chemotherapy resistance of the main reasons. Studies have shown that there are many mechanisms leading to MDR. The most important mechanism is the overexpression of multidrug resistance (mdr_1) gene, which leads to the increase of the content of P-glycoprotein (P-plycoprotein)