目的:合成新的胰岛素增敏剂西格列羧[(2S)-2-[2-(4-氟苯甲酰)苯胺]-3-{[4-(2-咔唑-9-基)-乙氧基]苯基}丙酸]。方法:以4-氟苯甲酰环己酮、L-酪氨酸甲酯、1,2-二澳乙烷以及卡巴唑为原料,经3步反应合成目标化合物。结果:原料易得,反应条件温和,总收率达10.8％。结论:该方法合成路线短,操作简便,反应可控性好,适合于工业生产。 OBJECTIVE: To synthesize a novel insulin sensitizer, [(2S) -2- [2- (4-fluorobenzoyl) aniline] -3- {[4- (2-carbazol-9-yl) -ethoxy] phenyl} propionic acid]. Methods: The target compounds were synthesized via 3 steps using 4-fluorobenzoylcyclohexanone, L-tyrosine methyl ester, 1,2-dioxane and carbazole as starting materials. Results: The raw materials were easy to obtain and the reaction conditions were mild. The total yield was 10.8%. Conclusion: The method has the advantages of short synthesis route, simple operation, good reaction controllability and suitable for industrial production.