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近年来有报道,人摄入乙醇后,血浆胰泌素(secretin)浓度增加。Nishiwaki等观察了乙醇对狗的血浆胃泌素浓度及胰分泌的影响,并对其机理进行了探讨。选用杂种狗,雌雄不拘,事先给狗分别做胃瘘和胰瘘手术,术后三周进行实验。于实验前禁食18小时,然后将狗分成禁食和摄食两组。禁食组,在经外周静脉取血和收集胰液作为正常测定值后30、60、90分钟,分别经胃瘘灌注40%乙醇(2g/kg),于灌注后10和15分钟,各取血和收集胰液;摄食组,在取对照血和收集胰液后30分钟,按下法分组:(1)单纯喂饲肉食组;(2)饲肉+胃内灌注乙醇组;(3)甲氰咪胍+饲肉+灌注乙醇组,即在喂肉前10分钟静脉注射甲氰咪胍150mg;(4)以生理盐水代替乙醇作为对照组。同时作者还用上述方法,观察了有海氏小胃狗在30分钟内胃酸排出量。各组均以禁食组方法取
In recent years, it has been reported that after human intake of ethanol, the concentration of plasma secretin increases. Nishiwaki et al observed the effect of ethanol on plasma gastrin and pancreatic secretion in dogs and explored its mechanism. Selection of hybrid dogs, both male and female, prior to the dogs were made of gastric fistula and pancreatic fistula surgery, three weeks after the experiment. Fasting for 18 hours before the experiment, then the dogs were divided into fasting and feeding two groups. In the fasted group, 40% ethanol (2g / kg) was infused through the gastric fistula at 30, 60 and 90 minutes after blood was drawn from the peripheral vein and the pancreatic juice was collected as the normal measurement value. At 10 and 15 minutes after the perfusion, And collecting the pancreatic juice. In the feeding group, 30 minutes after taking the control blood and collecting the pancreatic juice, the patients were divided into the following groups according to the following methods: (1) feeding the meat group alone; (2) feeding the meat and stomach into the ethanol group; (3) Guanidine + forage meat + ethanol infusion group, that is, 10 minutes before the feed of meat atemectin guanidine 150mg; (4) saline instead of ethanol as a control group. At the same time, the author also used the above method to observe the gastric acid secretion of Haishuijiewei dogs within 30 minutes. All groups were fasted group method