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背景:冠状动脉斑块进展及其不稳定性与动脉壁的扩张性重构相关。然而,斑块稳定化治疗过程中的重构反应及其与脂质代谢和炎症标记物之间的关系尚不完全清楚。方法和结果:收集了REVERSAL(强化降脂治疗逆转动脉粥样硬化)试验中比较18个月强化降脂治疗与中度降脂治疗的连续血管内超声(IVUS)资料。
BACKGROUND: Coronary plaque progression and instability are associated with dilative remodeling of the arterial wall. However, the relationship between the remodeling response during plaque stabilization and its association with lipid metabolism and inflammatory markers is not fully understood. METHODS AND RESULTS: Continuous endovascular ultrasound (IVUS) data comparing intensified lipid-lowering therapy with moderate lipid-lowering therapy for 18 months in REVERSAL (Reinforced Antidiabetic Therapy Reverse Atherosclerosis) trial were collected.