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过去认为结节病与T细胞功能低下、B细胞功能亢进有关。采用支气管肺泡灌洗方法后发现本病肺局部的T细胞、B细胞、单核细胞及巨噬细胞的机能均亢进。1991年9月在京都召开的第12次世界结节病会议上,对长达15年的本病的描述进行了修订。1.结节病的病因有人认为结核菌是本病的病原菌,也有人认为是链球菌,但尚无准确的结果。还有本病系由非单一原因所致的看法。2.结节病肺损伤的机制因某种未明的病因致使肺泡巨噬细胞活化(AM),与T细胞一起引起肺泡隔炎,进而形成肉芽肿。后者自行缓解较多,也可破坏
In the past that sarcoidosis and T cell dysfunction, B cell hyperthyroidism related. The use of bronchoalveolar lavage method found that local lung T cells, B cells, monocytes and macrophages are hyperthyroidism. In September 1991 in Kyoto held the twelfth world sarcoidosis meeting, up to 15 years of description of the disease was revised. 1. The cause of sarcoidosis Some people think that TB is the pathogen of the disease, some people think that is Streptococcus, but no accurate results. There are also non-single cause of the disease caused by the view. 2. The mechanism of sarcoidosis lung injury caused by some unknown cause of alveolar macrophage activation (AM), together with T cells caused by alveolar septoremia, and thus the formation of granulomas. The latter relieve more, but also damage