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运用微管吸吮技术定量测量了动脉粥样硬化过程中吞噬细胞的黏弹性特性。选择标准线性固体模型(Kelvin模型)拟合实验结果,并用Kelvin模型的三个黏弹性参数来比较动脉粥样硬化过程中不同阶段吞噬细胞的力学特性。实验结果表明,在动脉粥样硬化形成以前,单核细胞在进入血管内膜变成巨噬细胞后,其细胞的变形能力就已经开始下降,细胞的刚性增加;在动脉粥样硬化初步形成后,泡沫细胞的变形能力进一步下降。我们认为,吞噬细胞在吞噬低密度脂蛋白后变形能力的恶化可能会直接影响细胞的爬行能力,致使泡沫细胞滞留于动脉血管内膜,导致动脉粥样硬化斑块的形成。这一研究结果对于动脉粥样硬化的研究可能具有重要的参考意义。
Microtubule sucking technique was used to quantitatively measure the viscoelasticity of phagocytes during atherosclerosis. The standard linear solid model (Kelvin model) was chosen to fit the experimental results. The three viscoelastic parameters of the Kelvin model were used to compare the mechanical properties of phagocytes in different stages of atherosclerosis. Experimental results show that before the formation of atherosclerosis, monocytes enter the vascular intima into macrophages, the cell’s deformability has begun to decline, the rigidity of the cells increased; in the initial formation of atherosclerosis , The deformability of foam cells further decreased. In our opinion, the deterioration of the deformability of phagocytes after phagocytosis of LDL may directly affect the cell’s ability to crawl, causing the foam cells to remain in the intima of the arterial wall, resulting in the formation of atherosclerotic plaque. The results of this study may have important reference value for the study of atherosclerosis.