细胞周期检测点激酶 2 (Chk2 )是近来新发现的一个细胞周期调控蛋白。在发生DNA损伤或复制阻滞后 ,细胞通过不同途径激活Chk2 ,进而作用于下游不同的靶蛋白 ,最终激活G1、S和 (或 )G2 /M期检测点机制 ,使细胞周期进程发生阻滞 ,同时激活修复相关基因的转录 ,促进细胞对损伤进行修复。Chk2基因突变在肿瘤发病中具有一定意义 ,但其发生率较低。肿瘤细胞可通过激活Chk2来加强损伤修复 ,导致耐药表型产生 Cell cycle checkpoint kinase 2 (Chk2) is a newly discovered cell cycle regulatory protein. In the event of DNA damage or replication block, the cells activate Chk2 through different pathways, and then act on different downstream target proteins, eventually activating G1, S and / or G2 / M phase detection mechanism, blocking cell cycle progression , At the same time activate the transcription of the repair-related genes and promote cells to repair the damage. Chk2 gene mutation in the pathogenesis of cancer has a certain significance, but its incidence is low. Tumor cells can enhance damage repair through the activation of Chk2, leading to drug-resistant phenotype