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作者报告持续输注小剂量皮质醇时,正常人和柯兴氏病人的内源性ACTH分泌情况。2例柯兴氏病人均有典型的临床和实验室表现,其中1例于9天后死于支气管肺炎,尸检时发现垂体前叶有嫌色性微腺瘤。正常对照为健康志愿者。方法于受试者两上臂各放置静脉导管,1根作输液和滴注皮质醇用,另1根每隔15min抽血标本1次。柯兴氏病人在第1、第2、第3小时中各以5、10、15mg/h剂量的皮质醇静滴;健康受试者以3、6、9、12mg/b剂量的皮质醇静滴。ACTH用生物法测定,血浆皮质类固醇用荧光法测定。
The authors report the endogenous ACTH secretion in normal and Cushing’s patients with continuous infusion of low-dose cortisol. 2 cases of Cushing’s patients have typical clinical and laboratory performance, of which 1 died of bronchial pneumonia after 9 days, autopsy found anterior pituitary with chromophobe microadenomas. Normal control for healthy volunteers. Methods Venous catheters were placed on the two upper arms of the subjects, one for infusion and infusion of cortisol, and the other for blood samples once every 15 minutes. Cushing’s patients in the first, second and third hours of 5,10,15 mg / h doses of cortisol intravenous; healthy subjects to 3,6,9,12 mg / b dose of cortisone static drop. ACTH was determined by bioassay and plasma corticosteroid was measured by fluorometry.