许多证据表明α-黑色素细胞刺激素 (α- MSH)是一种内源性的神经免疫调节肽 ,可抑制发热与主要类型的实验性炎症 .在人类 ,炎性部位的 α- MSH浓度升高 ,感染性疾病或内毒素注射后血浆中 α- MSH浓度也升高 .α- MSH有拮抗前炎性细胞因子的作用 ,并可抑制其生成 .这种抗细胞因 There is ample evidence that α-melanocyte-stimulating hormone (α-MSH) is an endogenous neuroimmunoregulatory peptide that inhibits fever and the major types of experimental inflammation. In humans, elevated concentrations of α-MSH at inflammatory sites , Infectious disease or endotoxin injection plasma α-MSH concentration also increased.α-MSH antagonism of pro-inflammatory cytokines and can inhibit the formation of this anti-cytokine