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目的探讨喘息性支气管炎血清嗜酸性粒细胞趋化蛋白检测临床意义。方法选取201.02～2013.03符合入选标准的呼吸道合胞病毒感染喘息性支气管炎患儿78例,并选取同期进行健康体检儿童50例为健康体检组,检测嗜酸性粒细胞趋化蛋白(Eotaxin)、单核细胞趋化蛋白-1检测(MCP-1)并进行观察。结果轻度喘息组、重度喘息组、健康体检组Eotaxin、MCP-1检测值观察,健康体检组检测值明显低于轻度喘息组、重度喘息组,经统计学比较P<0.01,差异有统计学意义;喘息性支气管炎分期观察嗜Eotaxin、MCP-1检测值,并进行比较,急性期Eotaxin、MCP-1检测值显著高于恢复期、临床痊愈期经,统计学分析P<0.05差异有统计学意义。结论血清嗜酸性粒细胞趋化蛋白与气道高反应程度呈正相关,对喘息性支气管炎进行血清嗜酸性粒细胞趋化蛋白检测可以对疾病程度及临床分期进行指导。
Objective To investigate the clinical significance of serum eosinophil chemotaxis protein in asthmatic bronchitis. Methods A total of 78 children with asthmatic bronchitis were enrolled in this study. The children of asthmatic bronchitis were enrolled in this study from July, 201 to March, 2013. Fifty healthy children were enrolled in the study. Eotaxin, Nuclear chemotactic protein-1 assay (MCP-1) was performed and observed. Results The detection values of Eotaxin and MCP-1 in mild asthmatic group, severe asthmatic group and healthy group were significantly lower than those in mild asthmatic group and severe asthmatic group (P <0.01, P <0.01) The values of Eotaxin and MCP-1 in stasis bronchitis staging were compared and observed. The detection values of Eotaxin and MCP-1 in acute stage were significantly higher than those in recovery stage and clinical recovery stage. The difference was statistically significant (P <0.05) Statistical significance. Conclusions Serum eotaxin protein is positively correlated with the degree of airway hyperresponsiveness. Serum eosinophil protein detection of asthmatic bronchitis can guide the disease severity and clinical stage.