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日本研究癌的历史悠久,在日本发行的癌研究专门刊物《癌》(GANN)创刊于1907年,比最早的法国刊物迟了四年,目前在世界上拥有众多读者。1915年山极、市川首先用煤焦油诱发免耳生癌,1932年用正氨偶氮甲苯使大白鼠人工肝癌获得成功。说明在化学致癌研究领域里战前就有光辉的历史。战后日本关于致癌研究的趋向是以化学致癌为重点,本文结合国外的重要研究试做回顾性的叙述。致癌机制(总和学说和二阶段学说) 在DAB(4—二甲基氨基偶氮苯、奶油黄)肝癌的基础上,1948年德鲁克莱提出总和学说(累加学说),认为由于致癌物质的特点,其所造成的不可逆性变化不断蓄积,结果导致癌的发生。
Japan has a long history of cancer research. Its special issue in cancer research, Cancer (GANN), was published in Japan in 1907. It is four years later than the earliest French publication and currently has many readers in the world. In 1915, Yamaguchi and Ichikawa first used coal tar to induce ear cancer, and in 1932, positive ammonia azotoluene was used to make artificial rat liver cancer succeed. It shows that before the war, there was a glorious history in the field of chemical carcinogenesis. The trend of post-war Japan on carcinogenic research is focused on chemical carcinogenesis. This article combines retrospective narratives with foreign studies. Carcinogenic mechanism (Sum Theory and Second Stage Doctrine) Based on DAB (4-Dimethylaminoazobenzene, Cream Yellow) liver cancer, Drucker proposed the sum theory (accumulation theory) in 1948, arguing that because of carcinogens Characteristics, the irreversible changes caused by it continue to accumulate, resulting in the occurrence of cancer.