论文部分内容阅读
目的探讨糖尿病大动脉生物力学特性重建以及与高血压、高血糖的关系。方法以ＳＴＺ诱导ＳＨＲ大鼠和ＳＤ大鼠分别建立伴有（ＳＨＲＤＭ组）和不伴有（ＳＤＤＭ组）高血压的糖尿病动物模型，对其腹主动脉的在体顺应性和弹性模量进行研究。结果糖尿病４周开始出现顺应性降低。ＳＨＲＤＭ组从４周起、ＳＤＤＭ组从８周起，出现Ｅｐ、Ｅv和Ｅｉｎｃ增加，增幅随病程而增大，ＳＨＲＤＭ组的增幅大于ＳＤＤＭ。结论腹主动脉各力学特性参数中，顺应性改变最早，可作为评价血管功能的敏感指标。高血糖和高血压均可使Ｅｐ增大，高血糖的作用大于高血压。
Objective To investigate the reconstruction of biomechanical properties of diabetic aorta and its relationship with hypertension and hyperglycemia. Methods The animal models of diabetes mellitus (SHRDM) and SDDM without hypertension (STDM) were established by STZ-induced SHR and SD rats, respectively. The in-vivo compliance and elastic modulus of the abdominal aorta were studied . Results 4 weeks after onset of diabetes began to reduce compliance. In the SHRDM group, from the 4th week onwards, Ep, Ev and Einc increased in the SDDM group from the 8th week onwards. The increase rate increased with the course of disease and the increase rate of SHRDM group was higher than SDDM. Conclusion Abdominal aorta mechanical properties of the parameters, the earliest changes in compliance, can be used as a sensitive indicator of vascular function. Hyperglycemia and hypertension can make Ep increased, the role of hyperglycemia than hypertension.