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目的分析丙型肝炎病毒感染者血清YKL-40浓度,探讨丙型肝炎病毒感染者血清YKL-40水平变化与肝功能损害程度的关系。方法收集丙型肝炎病毒感染者107例,分成丙型肝炎病毒携带者、轻度慢性丙型肝炎患者和中度慢性丙型肝炎患者三组。通过酶联免疫吸附法测定丙型肝炎病毒感染者血清YKL-40的水平。结果丙型肝炎病毒携带者、轻度慢性丙型肝炎患者和中度慢性丙型肝炎患者血清YKL-40浓度均值和中值均高于正常对照组(P<0.01),且血清YKL-40的水平随丙型肝炎病毒感染者肝功能损害程度的加重而增加。结论血清YKL-40升高是肝纤维化的特征之一,丙型肝炎病毒感染者血清YKL-40水平随肝功能损害程度的加重而增加,这预示随肝功能损害程度加重丙型肝炎病毒感染者出现肝纤维化的可能性增加。
Objective To analyze the serum concentration of YKL-40 in patients with hepatitis C virus infection and to explore the relationship between the changes of serum YKL-40 level and the degree of liver dysfunction in patients with hepatitis C virus infection. Methods A total of 107 patients with hepatitis C virus were collected and divided into three groups: hepatitis C virus carriers, patients with mild chronic hepatitis C and patients with moderate chronic hepatitis C. The level of serum YKL-40 in hepatitis C virus infected patients was determined by enzyme-linked immunosorbent assay. Results The mean and median of serum YKL-40 levels in patients with hepatitis C virus, mild chronic hepatitis C and moderate chronic hepatitis C were significantly higher than those in normal controls (P <0.01), and serum YKL-40 The level of hepatitis C virus infection with increased severity of liver damage. Conclusions Elevated serum level of YKL-40 is one of the characteristics of liver fibrosis. The level of serum YKL-40 in hepatitis C virus infected patients increases with the severity of liver dysfunction, which indicates that hepatitis C virus infection aggravates with the severity of liver dysfunction The possibility of liver fibrosis increased.