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目前 ,尽管不断有新的化疗药物和化疗方案推出 ,但肿瘤细胞对多种化疗药物产生的多药耐药性(ｍｕｌｔｉｄｒｕｇｒｅｓｉｓｔａｎｃｅ ,ＭＤＲ)仍是化疗失败的主要原因。所谓ＭＤＲ系指肿瘤对一种抗肿瘤药物出现耐药的同时 ,对其他许多结构各异、作用机制不同的抗肿瘤药物亦产
At present, despite the introduction of new chemotherapeutic agents and chemotherapy regimens, the multidrug resistance (MDR) of tumor cells to multiple chemotherapeutic agents is still the main reason for chemotherapy failure. The so-called MDR means that the tumor is resistant to an antitumor drug and it is also produced by many other antitumor drugs with different structures and different mechanisms of action.