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为了了解我国非免疫缺陷相关B淋巴瘤是否与EBV有关，我们采用EBVencodedsmallRNA（EBER－1）原位杂交对127例非免疫缺陷相关B淋巴瘤进行了研究。结果显示，其中8例瘤细胞核内有EBER－1的表达（中心母细胞型4例；淋巴浆细胞样型、浆细胞型、免疫母细胞型和不能分型的高度恶性B细胞淋巴瘤各1例），检出率为6．3％。这一结果与欧美的情况一致（5％左右）．但明显低于我国何杰金病（82％）及T淋巴细胞（62％）的检出率，因此提示EBV在非免疫缺陷B淋巴瘤发病中的作用是有限的，主要致病因素还有待进一步研究。
To understand whether non-immune-defective B-lymphoma in China is associated with EBV, we used EBV encoded small RNA (EBER-1) in situ hybridization to study 127 non-immune-defective B-lymphomas. The results showed that there were 8 cases of EBER-1 expression in the nucleus of tumors (4 cases of centroplastic type; high-grade malignant B-cell lymphomas of lymphoplasmacytic, plasma cell, immunoblastic, and non-differentiable types 1 Example), the detection rate was 6.3%. This result is consistent with the situation in Europe and the United States (about 5%). However, it was significantly lower than the detection rate of Hodgkin’s disease (82%) and T lymphocytes (62%) in China, suggesting that the role of EBV in the pathogenesis of non-immune-deficient B lymphoma is limited, and the main pathogenic factors have yet to be resolved. further research.