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目的:探讨不同民族冠心病患者发生阿司匹林抵抗(AR)的临床特点。方法:选择148例冠心病住院患者,汉族72例,维吾尔族76例。服用阿司匹林100mg/d,连服7d,分别以二磷酸腺苷(ADP)和花生四烯酸(AA)为诱导剂,检测患者的血小板聚集率,观察阿司匹林抵抗(AR)与半抵抗(ASR)的临床特点。结果:(1)148例患者中AR检出率为5.4%(8/148),ASR检出率为27.7%(41/148)。(2)多因素logistic回归分析显示:年龄、性别及低密度脂蛋白浓度对AR或ASR均有影响。(3)维吾尔族和汉族患者AR及ASR检出率差异均无统计学意义。结论:服用阿司匹林的冠心病患者中存在着AR现象;AR及ASR检出率与族别无关。
Objective: To investigate the clinical features of aspirin resistance (AR) in different nationalities with coronary heart disease. Methods: 148 cases of coronary heart disease inpatients, 72 Han cases, 76 Uighurs. Patients were given aspirin 100 mg / d for 7 days. The ADP and arachidonic acid (AA) were used as inducers respectively to detect the platelet aggregation rate. The aspirin resistance (AR) and semi-resistance (ASR) The clinical features. Results: (1) In 148 patients, the detection rate of AR was 5.4% (8/148) and the detection rate of ASR was 27.7% (41/148). (2) Multivariate logistic regression analysis showed that age, sex and low density lipoprotein concentrations had effects on AR or ASR. (3) There was no significant difference in the detection rates of AR and ASR between Uighur and Han nationality patients. Conclusion: There is AR in patients with coronary heart disease taking aspirin. The detection rate of AR and ASR has nothing to do with family.