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通过对兔血细胞内２′，５′－寡聚腺苷酸合成酶（２′，５′－ＯＡＳＥ）诱导形成的研究，发现聚肌苷酸与聚胞苷酸双链复合物（ｐｏｌｙ（Ｉ）·ｐｏｌｙ（Ｃ））只能诱导单核型细胞（ＰＢＭＣ）产生２′，５′－ＯＡＳＥ，而新城疫病毒（ＮＤＶ）、红细胞生成素（ＥＰＯ）可同时刺激ＰＢＭＣ和总红细胞中２′，５′－ＯＡＳＥ水平的上升。实验证明总红细胞中２′，５′－ＯＡＳＥ定位于网织细胞中，苯肼、ＮＤＶ和ＥＰＯ引起总红细胞中２′，５′－ＯＡＳＥ活性的增加与外周血中网织细胞的增加有直接关系。注射ｐｏｌｙ（Ｉ）·ｐｏｌｙ（Ｃ）、ＮＤＶ和ＥＰＯ可使单位ＰＢＭＣ的２′，５′－ＯＡＳＥ比对照本底提高６倍左右，从而提示是一种诱导作用，考虑到前两种物质是兔干扰素的高效诱导剂，有理由认为它们是通过干扰素而发挥作用，而ＥＰＯ诱导的酶形成的时间过程类似于人干扰素，有可能是直接作用的结果。
Through the study on the induction of 2 ’, 5’-oligoadenylate synthase (2’, 5’-OASE) in rabbit blood cells, it was found that poly inosinic acid and polylysine double-strand complex ) · Poly (C) can only induce the production of 2 ’, 5’-OASE from mononuclear cells (PBMCs), while Newcastle disease virus (NDV) and erythropoietin (EPO) , 5’-OASE level rise. Experiments show that 2 ’, 5’-OASE of erythrocytes localized in reticulocytes. Phenylhydrazine, NDV and EPO cause direct increase of 2’, 5’-OASE activity in total erythrocytes and direct increase of reticulocytes in peripheral blood relationship. Injection of poly (I) · poly (C), NDV and EPO increased the 2 ’, 5’-OASE of PBMCs by about 6-fold compared with the control background, suggesting that it is an inducing effect. Considering that the first two substances are Rabbit interferon efficient inducers, it is reasonable to believe that they play a role by interferon, and EPO-induced enzyme formation process similar to human interferon, may be the direct result of the action.