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目的:探讨小猪心脏磁共振成像(CMR)的优化方法 ,初步观察T_1 mapping定量值在小猪心肌缺血或梗死的变化。方法:选择13只正常中华小型猪;初次扫描1周后,于冠状动脉左前降支近中段交界区置入蛋白缩窄环,4周时慢性心肌缺血小猪模型形成,并行第2次MRI检查。2次检查均行增强扫描前后的T_1 mapping扫描,分析下壁与前间壁T_1值的变化,提出CMR扫描优化方案。结果:通过改进、优化扫描过程中的序列顺序及参数,缩减了扫描时间,提高了图像质量。结果显示,平扫时,建模后前间壁的T_1值较建模前明显增大(P<0.01);增强扫描时,建模后的前间壁T_1值则明显低于建模前(P<0.01)。结论:小猪心脏MRI扫描方案的优化提高了实验效率和图像质量;其T_1 mapping可用于判断心肌的缺血或梗死。
Objective: To investigate the optimization of piglet cardiac magnetic resonance imaging (CMR), and to observe the change of T_1 mapping quantitatively in myocardial ischemia or infarction. Methods: Thirteen normal Chinese miniature pigs were selected. One week after the first scan, a protein narrowing ring was placed at the junction of the left anterior descending artery of the coronary artery in the proximal and middle segments. The model of chronic myocardial ischemia piglets was formed at 4 weeks. The second MRI an examination. The T_1 mapping before and after the enhanced scan was performed in both examinations. The change of T_1 between the inferior wall and the anterior wall was analyzed, and the optimized scheme of CMR scanning was proposed. Results: By improving and optimizing the sequence and parameters of the scanning process, the scanning time was reduced and the image quality was improved. The results showed that the T 1 value of the anterior wall after modeling was significantly higher than that before modeling (P <0.01), while the T 1 value of the anterior wall after modeling was significantly lower than that before modeling (P < 0.01). Conclusion: Optimization of the piglet cardiac MRI scanning scheme can improve the experimental efficiency and image quality. The T_1 mapping can be used to judge the myocardial ischemia or infarction.