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加拿大药品不良反应监测部门(CADRMP)发出警告:鼓膜穿孔患者应用氨基糖苷类滴耳剂时会引起耳毒性。1981年至2000年10月期间,CADRMP收到18份鼓膜穿孔或实施鼓室成形术的患者,使用庆大霉素+倍他米松的滴耳剂((Gara-sone(?))后引起耳毒性的可疑报告,其中16份前庭疾患,2份听力丧失。此外,还收到1份与使用庆大霉素滴耳剂有关的头昏和眩晕的报告;另一梅尼
Canadian Agency for Adverse Drug Reactions (CADRMP) warns that patients with tympanic membrane perforation can cause ototoxicity when using aminoglycosides. Between 1981 and October 2000, CADRMP received 18 patients with tympanic membrane perforation or tympanoplasty that caused ototoxicity with gentamicin + betamethasone (Gara-sone (?)) Suspicious reports of 16 cases of vestibular disorders and 2 hearing losss.In addition, 1 report of dizziness and dizziness associated with gentamicin eardrops was received;