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硒是人和哺乳动物必需的微量元素,是谷胱甘肽过氧化物酶(GPx)的重要成分,参与清除体内的H_2O_2和有机过氧化物,在抗脂质过氧化、保护生物膜正常结构与功能方面有重要作用。大量研究表明,缺硒动物心肌、肝脏和肾脏等组织线粒体膜结构和功能异常,一般认为上述异常改变是缺硒导致体内重要含硒的抗氧化酶—GPx活性下降,机体抗氧化能力减弱和脂质过氧化增强的结果。但是细胞过氧化损害发生与否及损害程度除了与细胞抗氧化能力有关外,还与自由基生成有关,取决于二者间的平衡。目前,有关低硒时线粒体内膜呼吸链O_2生成有何变化尚不清楚。本文观察缺硒大鼠心肌、
Selenium is an essential trace element for human and mammals, and is an important component of glutathione peroxidase (GPx), which is involved in the clearance of H 2 O 2 and organic peroxides in the body and plays an important role in anti-lipid peroxidation and protection of the normal structure of biofilms And function has an important role. A large number of studies have shown that the mitochondrial membrane structure and function abnormalities in myocardium, liver and kidney of selenium-deficient animals are generally believed that the above-mentioned abnormal changes are the result of the deficiency of selenium leading to the decrease of the activity of important selenium-containing antioxidant enzyme GPx in the body, the decrease of antioxidant capacity, Results of hyperoxidation. However, the occurrence of cell damage and damage to peroxidation in addition to cellular antioxidant capacity, but also with the generation of free radicals, depending on the balance between the two. At present, it is unclear what happens to the O_2 generation in mitochondrial respiratory chain when selenium is depleted. This paper observed myocardial selenium deficiency,