在实验性动物研究中已证实PUVA治疗可引起角膜浑浊和白内障,但尚未有报告在PUVA治疗的患者中产生白内障。本文报告了340例长期(超过6个月)作PUVA治疗患者,在治疗开始前或治疗开始6周内作初次眼科检查,以后每隔6个月重复检查视觉敏锐度,折射度及眼底镜检查。在开始时裂隙灯检查134(39.3%)/340例有晶状体浑浊。PUVA治疗期间,20例患者产生白内障,340例患者均未见视网膜变化。本研究8-MOP口服积累量为 PUVA treatment has been shown to cause corneal opacity and cataracts in experimental animal studies, but cataract has not been reported in PUVA treated patients. This article reports 340 long-term (more than 6 months) patients treated with PUVA, before the start of treatment or initial treatment within 6 weeks for the first eye examination, after every 6 months after repeated inspection of visual acuity, refractive index and ophthalmoscopy . At the beginning of slit lamp examination 134 (39.3%) / 340 cases had lens opacity. During the PUVA treatment, 20 patients developed cataracts and none of 340 patients had retinal changes. This study 8-MOP oral accumulation of