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目的:研究米非司酮联合甲氨蝶呤治疗异位妊娠的临床疗效。方法:2012年7月-2013年7月收治异位妊娠患者58例,随机将患者分为对照组和观察组,每组29例。对照组采取米非司酮作为治疗性药物给予处理;观察组在对照组的治疗基础上,增加甲氨蝶呤进行联合治疗。治疗周期结束之后,比较两组的治疗效果,并采取统计学分析。结果:经过治疗之后,观察组总治疗有效率89.5%。对照组总治疗有效率57.9%。两组比较差异有统计学意义(P<0.05)。观察组在住院时间、β-HCG恢复时间、阴道无规则出血时间、腹痛时间均优于对照组,差异均有统计学意义(P<0.05)。两组在药物不良反应的比较上差异无统计学意义(P>0.05)。结论:米非司酮联合甲氨蝶呤治疗异位妊娠具有良好效果,值得在临床上大力推广。
Objective: To study the clinical efficacy of mifepristone and methotrexate in the treatment of ectopic pregnancy. Methods: From July 2012 to July 2013, 58 patients with ectopic pregnancy were enrolled. Patients were randomly divided into control group and observation group, with 29 cases in each group. The control group to take mifepristone as a therapeutic drug treatment; observation group in the control group based on the treatment, an increase of methotrexate for treatment. After the end of the treatment period, the treatment effects of the two groups were compared and a statistical analysis was taken. Results: After treatment, the observation group, the total effective rate of 89.5%. The control group, the total effective rate of 57.9%. The difference between the two groups was statistically significant (P <0.05). The observation group in hospitalization time, recovery time of β-HCG, vaginal irregular bleeding time, abdominal pain were better than the control group, the difference was statistically significant (P <0.05). There was no significant difference in ADR between the two groups (P> 0.05). Conclusion: The combination of mifepristone and methotrexate has good effect on ectopic pregnancy, which is worth to be popularized clinically.