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Angew.Chem.Int.Ed.2014,53,7629~7633含有三氟甲基基团的分子已经获得了广泛的重视,因为三氟甲基具有独特的电负性,新陈代谢的稳定性和亲脂性使得医药品、农药品、材料的生物化学性质得到极大的改善.因此国际上现阶段的工作主要是将三氟甲基基团引入到目标分子中.到现在为止,绝大多数的工作主要是针对双键的三氟甲基化官能团化反应,对于叁键的官能团化尤其是内部叁键的三氟甲基化反应探索的非常少.兰州大学功能有机分子国家重点实验室梁永民课题组首次利用铜
Angew. Chem. Int. Ed. 2014, 53, 7629-7633 molecules containing trifluoromethyl groups have received a great deal of attention because of their unique electronegativity, metabolic stability and lipophilicity Pharmaceuticals, pesticides, materials, biochemical properties have been greatly improved, so the international phase of the work is mainly the introduction of trifluoromethyl groups into the target molecule so far, the vast majority of work is mainly Trifluoromethylation of double bond functionalization reaction, for the triple bond functional group, especially the internal triple bond trifluoromethylation to explore very little.Lanzhou University State Key Laboratory of functional organic molecules Liang Yongmin task force for the first time copper