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目的探讨慢传输型便秘(STC)与5-羟色胺转运体基因启动子区(5-HTTLPR)多态性的相关性。方法采用聚合酶链反应技术检测54例STC患者(STC组)和100例正常对照者5-羟色胺转运体基因启动子区多态性的分布频率。结果SIC组5-羟色胺转运体基因启动子区S/S基因型和S等位基因频率分别为72．2%、83．3%。对照组S/S基因型和S等位基因频率分别为50．0%、72．5%,两组间的差异有统计学意义(P＜0．05)。STC组按性别、发病年龄(小于45岁和等于或超过45岁)分组后,比较5-HTTLPR基因多态性差异无统计学意义,但按结肠运输试验72 h后排出标志物是否达到40%分组后,未达到40%组S/S基因型频率明显高于达到组(71．7% vs 42．6%),差异有统计学意义(P＜0．05)。结论5-HTTLPR的S/S型可能参与了慢传输型便秘的发病机制。
Objective To investigate the association between slow transit constipation (STC) and serotonin transporter gene promoter region (5-HTTLPR) polymorphism. Methods The distribution of serotonin transporter gene polymorphism in 54 STC patients (STC group) and 100 normal controls was detected by polymerase chain reaction (PCR). Results The frequencies of S / S genotype and S allele in serotonin transporter gene promoter region in SIC group were 72.2% and 83.3%, respectively. The frequencies of S / S genotype and S allele in the control group were 50.0% and 72.5%, respectively, with significant difference between the two groups (P <0.05). STC group by sex, age (less than 45 years old and equal to or older than 45 years) grouped, compared 5-HTTLPR gene polymorphism was no significant difference, but according to the colon transport test 72 hours after the discharge of markers to reach 40% After grouping, the frequency of S / S genotypes in the group not reached 40% was significantly higher than that in the group reached 71.7% vs 42.6% (P <0.05). Conclusion The S / S type of 5-HTTLPR may be involved in the pathogenesis of slow transit constipation.