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目的探讨低分子肝素钙和氯吡格雷联合治疗不稳定型心绞痛(UA)的临床疗效。方法采用单盲、对照的完全随机化方法。首次给予负荷剂量的氯吡格雷300mg口服,此后为75mg、1次/d,同时给予低分子肝素钙5000u皮下注射,每12h1次,连用1周。结果共入选UA患者80例,实验组与对照组各40例,实验组总有效率达90.0%,对照组总有效率仅为42.5%,两组差异显著P<0.05,实验组心脏事件发生率7.5%,对照组心脏事件发生率32.5%,两组差异显著P<0.01。结论低分子肝素钙和氯吡格雷联合应用治疗不稳定型心绞痛疗效显著,并且明显降低心脏事件发生率,无明显副反应。
Objective To investigate the clinical efficacy of low molecular weight heparin and clopidogrel in the treatment of unstable angina pectoris (UA). Methods A single-blind, controlled, completely randomized approach was used. The first dose of clopidogrel given a dose of 300mg orally, then 75mg, 1 / d, while giving low molecular weight heparin 5000u subcutaneous injection, every 12h1, once a week. Results A total of 80 UA patients were enrolled in this study. The experimental group and the control group had 40 cases each. The total effective rate was 90.0% in the experimental group and 42.5% in the control group, with significant difference between the two groups (P <0.05). The incidence of cardiac events 7.5% in the control group and 32.5% in the control group, with a significant difference between the two groups (P <0.01). Conclusion The combination of low molecular weight heparin and clopidogrel is effective in treating unstable angina pectoris and significantly reduces the incidence of cardiac events with no apparent side effects.