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目的 观察健肾片对IgA肾病大鼠肾组织一氧化氮(NO)、一氧化氮合酶(NOS)含量的影响,探讨健肾片对IgA肾病的作用机理。方法 采用口服牛血清白蛋白和葡萄球菌肠毒素B感染的复合方法,复制大鼠IgA肾病模型,并分别给予健肾片和雷公藤多苷片治疗,经硝酸还原法检测肾组织的NO、NOS含量。结果 健肾片可明显降低IgA肾病大鼠肾组织的NO、NOS含量。结论 健肾片治疗IgA肾病的作用机理之一是降低IgA肾病肾组织的NO、NOS含量。
Objective To observe the effect of Jianshen tablet on the contents of nitric oxide (NO) and nitric oxide synthase (NOS) in renal tissue of rats with IgA nephropathy, and to explore the mechanism of Jianshen tablet on IgA nephropathy. Methods The method of oral bovine serum albumin and staphylococcal enterotoxin B infection was used to replicate the rat model of IgA nephropathy. The rats were treated with Jianwei Tablet and Tripterygium glycosides tablets respectively. The NO and NOS in kidney tissues were detected by nitrate reduction method. content. Results Jianshen tablet can significantly reduce the content of NO and NOS in renal tissue of rats with IgA nephropathy. Conclusion One of the mechanisms of Jianshen tablets in treating IgA nephropathy is to reduce the content of NO and NOS in renal tissues of IgA nephropathy.