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目的:探讨脑力苏胶囊改善血管性认知障碍(VCI)大鼠认知障碍的作用机制。方法:采用永久性结扎双侧颈总动脉法制备慢性脑灌注不足VCI动物模型。实验大鼠随机分为假手术组、模型组、喜得镇组、脑力苏胶囊大剂量组、脑力苏胶囊中剂量组、脑力苏胶囊小剂量组。用水迷宫进行学习、记忆状态测定;借助光学显微镜对大脑额叶皮层组织形态结构进行观察。结果:大、中剂量脑力苏胶囊、喜得镇治疗后VCI大鼠学习、记忆障碍得到明显改善(P<0.05);大脑皮层神经元数量显著增多(P<0.05)。结论:脑力苏胶囊具有改善VCI大鼠学习、记忆障碍的能力,其可能的作用机制为改善脑血流量,对抗缺血缺氧,阻止皮质神经元变性坏死。
Objective: To explore the mechanism of Naolisu Capsule in improving cognitive impairment in vascular cognitive impairment (VCI) rats. METHODS: The animal model of chronic cerebral hypoperfusion VCI was established by permanent ligation of bilateral common carotid arteries. The experimental rats were randomly divided into sham operation group, model group, Xideng town group, Naolisu capsule high dose group, Naolisu capsule middle dose group, and Naolisu capsule low dose group. The water maze was used for learning and memory state measurements; the morphology and structure of the frontal cortex were observed with an optical microscope. Results: The learning and memory impairments of VCI rats after large and medium doses of Naolisu capsule and Xideng town were significantly improved (P<0.05). The number of neurons in cerebral cortex was significantly increased (P<0.05). Conclusion: Naolisu capsule can improve the ability of learning and memory impairment in VCI rats. Its possible mechanism is to improve cerebral blood flow, resist ischemia and hypoxia, and prevent degeneration and necrosis of cortical neurons.