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目的观察国产缬沙坦治疗轻中度原发高血压患者的降压疗效。方法选择轻中度高血压患者62例,分为实验组32例,对照组30例。试验组服用国产缬沙坦胶囊每日一次,每次80~160 mg,对照组服用进口缬沙坦胶囊每日1次,每次80~160 mg。两组均为晨起服药,疗程8周。结果实验组与对照组疗效基本相同(P>0.05),两组治疗2周后起效明显,至第6周达到最大降压幅度,两组在显效率之间差异无统计学意义,两组在DBP及SBP的T/P值间差异无统计学意义(P>0.05),两组无明显不良反应。结论国产缬沙坦与进口缬沙坦降压效果相同,国产缬沙组是值得临床推广应用的基础抗高血压药。
Objective To observe the antihypertensive effects of domestic valsartan in patients with mild to moderate essential hypertension. Methods Sixty-two patients with mild to moderate hypertension were selected and divided into experimental group (32 cases) and control group (30 cases). The experimental group took homemade valsartan capsules once daily for 80 ~ 160 mg. The control group took valsartan capsules once daily for 80 ~ 160 mg once daily. Both groups took the morning medication, treatment for 8 weeks. Results The experimental group and the control group had the same effect (P> 0.05). The two groups had significant effect after two weeks of treatment and reached the maximum depressurization amplitude by the sixth week. There was no significant difference between the two groups There was no significant difference between the T / P values of DBP and SBP (P> 0.05). There was no significant adverse reaction in both groups. Conclusion Domestic valsartan and imported valsartan antihypertensive effect is the same, the domestic valsartan group is worthy of clinical promotion and application of basic antihypertensive drugs.