目的探讨阻塞性睡眠呼吸暂停低通气综合征(Obstructive Sleep Apnea-Hypopnea Syndrome,OSAHS)患者行悬雍垂腭咽成形术(Uvu-lopalalophanyngoplasty,UPPP)后的疗效分析和总结。方法选取经多导睡眠图(polysomnography,PSG)检查并确诊的OSAHS的患者130例,98例和32例分别在全麻和局麻下行UPPP手术,其中16例行预防性气管切开术。结果术后随访六个月,六个月后复查PSG,AHI出现了明显的下降(t=19.953,P<0.01),最低SaO2出现了明显的升高(t=19.953,P<0.01)。其中36例随访三年,多为中重度OSAHS患者,其术后半年恢复情况良好,但是3年后其临床疗效有所下降,AHI出现了不同程度的回升(F=98.433,P<0.01),最低SaO2出现了不同程度的下降(F=27.913,P<0.01)。结论UPPP手术治疗OSAHS是目前最有效的方法之一,手术治疗的近期效果较好,但远期疗效仍不能让人满意。 Objective To investigate the curative effect of Uvu-lopalalophanyngoplasty (UPPP) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods A total of 130 patients with OSAHS diagnosed and diagnosed by polysomnography (PSG), 98 and 32 patients undergoing UPPP under general anesthesia and local anesthesia respectively, of whom 16 patients underwent prophylactic tracheotomy. Results Six months after the operation, PSG was observed after six months. The AHI was significantly decreased (t = 19.953, P <0.01) and the lowest SaO2 was significantly increased (t = 19.953, P <0.01). Among them, 36 cases were followed up for three years and mostly were patients with moderate to severe OSAHS. The postoperative recovery was good in six months, but the clinical efficacy declined after three years. The AHI showed some degree of recovery (F = 98.433, P <0.01) The lowest SaO2 decreased to some extent (F = 27.913, P <0.01). Conclusion The surgical treatment of OSAHS by UPPP is one of the most effective methods at present. The short-term effect of surgical treatment is better, but the long-term efficacy is still unsatisfactory.