心肌间质纤维化已日渐引起人们的重视，被认为是心衰进展中的有害因素之一。一氧化氮（ＮＯ）能抑制培养的血管平滑肌胶原合成，从而抑制细胞外基质的产生，而谢晓华［１］则报道左旋硝基精氨酸能引起原发性ＮＯ降低，产生持续性血压增高，导致心肌肥大和纤维化。为了解Ｎ... Myocardial interstitial fibrosis has gradually attracted people’s attention, is considered one of the harmful factors in the progression of heart failure. Nitric oxide (NO) can inhibit cultured vascular smooth muscle collagen synthesis, thereby inhibiting the production of extracellular matrix, and Xie Xiaohua [1] reported that L-nitroalginine can cause decreased primary NO, resulting in persistent blood pressure, Lead to cardiac hypertrophy and fibrosis. To understand N ...