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标记染色体除具有正常表型外,还可以引起智力低下,发育障碍及不孕症等。这些异常和标记染色体的大小、染色特性、嵌合性及家族出现率有关;异常可能是因为常染色质的存在导致了某些染色体片段的部分三体。因此有必要利用各种特异染色方法对标记染色体中异染色质和常染色质的组成加以鉴别。本文研究了在10000例产前诊断受检者中发现的15种标记染色体,分析方法包括G、C、Q和DA-DAPI染色。为了明确标记
In addition to the marker chromosome with normal phenotype, but also can cause mental retardation, developmental disorders and infertility. These abnormalities are related to the size, staining characteristics, chimerism and familial appearance of marker chromosomes. Abnormalities may be caused by the presence of euchromatin, which leads to partial trisomy of some chromosome fragments. Therefore, it is necessary to use a variety of specific staining methods for the identification of heterochromatin and euchromatin in the marker chromosomes. In this paper, 15 marker chromosomes found in 10,000 prenatal diagnosis subjects were analyzed by G, C, Q and DA-DAPI staining. In order to clearly mark