鼻腔鼻窦恶性肿瘤可由外源性和内源性的多种原因或因子单独或协同诱发。在体外病因中 ,绝大多数为化学致癌物所引起〔1〕。兹就近年来化学致癌物导致鼻腔鼻窦恶性肿瘤的研究进展综述如下。1　与生活方式有关的化学致癌物1.1　吸烟 :流行病学研究显示吸烟为鼻腔鼻窦癌的重要病因 Nasal sinus malignancy can be exogenous and endogenous a variety of causes or factors alone or in synergy. In vitro causes, the vast majority caused by chemical carcinogens 〔1〕. In recent years, chemical carcinogens lead to malignant nasal sinus cancer research are summarized below. 1 lifestyle-related chemical carcinogens 1.1 smoking: epidemiological studies have shown that smoking is an important cause of nasal sinus cancer