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目的 :研究mTOR/eIF -4EBP1信号通路的激活在粘液表皮样癌发生中的作用。方法 :用RT -PCR方法及Westen印迹分析测定粘液表皮样癌中mTOR和 4EBP1的表达。结果 :RT -PCR与Westen印迹分析的结果一致 :和正常组织相比 ,粘液表皮样癌中mTOR的表达明显增加 ,4EBP1的表达明显降低。结论 :口腔粘液表皮样癌中mTOR的表达增加和 4EBP1的表达明显降低可能是介导粘液表皮样暴发生的主要机制之一。
Objective: To investigate the role of mTOR / eIF -4EBP1 signaling pathway in the pathogenesis of mucoepidermoid carcinoma. Methods: The expressions of mTOR and 4EBP1 in mucoepidermoid carcinoma were determined by RT-PCR and Westen blotting. Results: The results of RT-PCR and Westen blot analysis showed that the expression of mTOR in mucoepidermoid carcinoma was significantly increased and the expression of 4EBP1 was significantly lower than that in normal tissue. Conclusion: The increased expression of mTOR and the decreased expression of 4EBP1 in oral mucoepidermoid carcinoma may be one of the main mechanisms of mucoepidermoid carcinogenesis.