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肺癌脑转移是肺癌患者重要的死因之一。非小细胞性肺癌脑转移发生率为54%左右,其中以大细胞未分化癌和腺癌较多见,鳞癌次之。小细胞肺癌(SCLC)在作出诊断时约有20%的患者已有脑转移,而在非小细胞肺癌患者的死亡病例尸检中脑转移发生率高达80%①。肺癌脑转移多数进展迅速,预后差,这就使得临床治疗相对困难,就肺癌脑转移治疗的研究进展作一综述。
Lung cancer Brain metastasis is one of the important causes of death in lung cancer patients. The incidence of non-small cell lung cancer brain metastasis is about 54%, of which large cell undifferentiated carcinoma and adenocarcinoma are more common, followed by squamous cell carcinoma. Approximately 20% of SCLC patients have had brain metastases at the time of diagnosis, and up to 80% of autopsy deaths in non-small cell lung cancer patients. Most of brain metastases of lung cancer progress rapidly, the prognosis is poor, which makes the clinical treatment is relatively difficult to review the progress of lung cancer brain metastases.