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用克山病病区粮以及分别加 Se 或/和加 I 喂饲大鼠,并观察机体甲状腺激素的代谢变化。结果发现,缺 I 可显著降低循环和肝脏的 T_4水平,循环总 T_3受 Se、I 影响不十分明显,但 FT_3变化较大。缺 Se 使肝 I 型5′-脱碘酶活性下降,并使肝 T_3生成减少,但因此引起 T_4堆积的现象只能在缺 Se加 I 组中出现。甲状腺组织的甲状腺激素水平因缺 I 而减少,但缺 Se 并未使其进一步下降,反而有较大幅度的升高,且同时使甲状腺肿胀加剧。循环促甲状腺激素(TSH)有相对稳定循环T_3水平的作用。TSH 与 T_4负相关。研究提示,不同 Se、I 营养状况对循环和组织甲状腺激素代谢影响不同,肝组织内源性甲状腺激素受 Se 水平影响较大。
Rats were fed with Keshan disease and Se plus and / or plus I separately, and the changes of thyroid hormone metabolism were observed. The results showed that the lack of I can significantly reduce the circulation and liver T 4 levels, the total circulating T 3 affected by Se, I is not very obvious, but FT 3 changes. Se deficiency led to liver type I 5’-deiodinase activity decreased, and to reduce the formation of hepatic T_3, but the phenomenon of accumulation of T_4 caused only in the lack of Se plus I group. Thyroid hormone thyroid hormone levels due to lack of I, but lack of Se did not make it further decline, but a more substantial increase, and at the same time so that the swelling of the thyroid increased. Cyclic thyroid stimulating hormone (TSH) has a relatively stable circulating T_3 level. TSH and T_4 negatively correlated. Studies suggest that different Se, I nutritional status of the circulating and tissue thyroid hormone metabolism of different endogenous thyroid hormone liver tissue affected by Se level.