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例1:男,51岁。于1964年2月25日作包皮环切术,因红汞消毒后引起多数发痒之丘疹,12小时后,给肌内注射盐酸异丙嗪50毫克。约5分钟,开始出现头昏、耳鸣,继之视力糊、听力减退、伴有四肢肌肉不自主之抽搐,意识清楚。体格检查:除脉搏每分钟140次外,余无特殊。给10%水合氯醛10毫升后,4小时后全身自觉及他觉症状逐渐消失,小便如常。5日后,以0.25毫克之盐酸异丙嗪0.1毫升作皮内试验,5分钟后在该处现红肿块2.5×2.5厘米大小,发痒,3日后始消失,生理盐水对照阴性,故诊断为盐酸异丙嗪过敏反应。
Example 1: Male, 51 years old. On February 25, 1964, the circumcision was performed, and most of itchy papules were caused by the disinfection of Mercury. Twelve hours later, 50 mg of promethazine hydrochloride was injected intramuscularly. About 5 minutes, began to appear dizziness, tinnitus, followed by vision paste, hearing loss, accompanied by limb muscle involuntary convulsions, conscious. Physical examination: In addition to the pulse of 140 times per minute, I no special. To 10% chloral hydrate 10 ml, 4 hours after the whole body consciously and his symptoms gradually disappear, urinate as usual. 5 days later, with 0.25 mg of promethazine hydrochloride 0.1 ml for intradermal test, 5 minutes after the red mass here 2.5 2.5 cm in size, itching, disappeared after 3 days, normal saline control negative, it was diagnosed as hydrochloric acid Promethazine allergy.