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目的探讨脂肪瘤性血管外周细胞瘤(lipomatous haemangiopericytoma,LHPC)的病理形态学特征、免疫表型及鉴别诊断。方法对3例LHPC进行免疫组化检测并文献复习。结果肿瘤由成熟的脂肪细胞、血管、良性的梭形细胞及不同程度胶原化的细胞外间质组成。免疫表型:肿瘤细胞CD34、CD99和BCL-2均()。结论 LHPC是一种少见的血管外周细胞瘤,由成熟脂肪细胞和血管外周细胞瘤样结构构成,与胸膜外孤立性纤维性肿瘤(solitary fibrous tumor,SFT)有多种共同特征,二者在临床特点、病理形态、免疫表型及超微结构方面都有共同特点,需注意二者的鉴别诊断。
Objective To investigate the pathomorphological features, immunophenotype and differential diagnosis of lipomatous haemangiopericytoma (LHPC). Methods Three cases of LHPC were examined by immunohistochemistry and reviewed. Results The tumor consisted of mature adipocytes, blood vessels, benign spindle cells and extracellular matrix with different degrees of collagenification. Immunophenotype: Tumor cells CD34, CD99 and BCL-2 both (). Conclusions LHPC is a rare perivascular neoplasm composed of mature adipocytes and perivascular tumor-like structures and has many common features with solitary fibrous tumor (SFT). Both of them are clinically Features, pathology, immunophenotype and ultrastructure have common features, should pay attention to the differential diagnosis of the two.