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目的 探讨膀胱移行细胞癌Survivin表达程度与分级的关系 ,以及尿脱落细胞中Survivin表达的意义。方法 采用免疫组化方法检测膀胱移行细胞癌中Survivin的表达 ,并用免疫组化图像分析系统分析其阳性率及表达程度。结果 Survivin在各级膀胱移行细胞癌中都有表达 ,但表达的程度不同 ,I级膀胱移行细胞癌呈弱阳性,Ⅱ级膀胱移行上皮细胞癌呈中度阳性,Ⅲ级膀胱移行上皮细胞癌呈强阳性。结论 Survivin是诊断膀胱移行细胞癌的优良指标。尿脱落细胞中Survivin的表达可作为诊断膀胱移行细胞癌的筛选试验
Objective To investigate the relationship between the expression of Survivin and the grade of bladder transitional cell carcinoma and the significance of Survivin expression in exfoliated urothelial cells. Methods The expression of Survivin in bladder transitional cell carcinoma was detected by immunohistochemistry. The positive rate and the expression level of Survivin were detected by immunohistochemistry. Results Survivin was expressed in bladder transitional cell carcinoma at all stages, but the expression level was different. The positive expression of Survivin in bladder transitional cell carcinoma of grade I was weakly positive while the level of transitional cell carcinoma of grade Ⅱ was moderately positive. The grade Ⅲ bladder transitional cell carcinoma Strong positive. Conclusion Survivin is an excellent marker for the diagnosis of bladder transitional cell carcinoma. Survivin expression in exfoliated urothelial cells can be used as a screening test for bladder transitional cell carcinoma