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α-苯甲酰胺基肉桂酸酯类化合物是合成苯丙氨酸及其衍生物的重要前体,对双键进行手性加氢即可得到光学活性氨基酸,对这类化合物的合成大多涉及噁唑酮的水解或β-位官能化氨基酸的β-消除,本文研究了亚氨酸酯1与芳醛2在乙醇钠-乙醇中的反应:
α-benzamidocinnamates are important precursors for the synthesis of phenylalanine and its derivatives. Chiral hydrogenation of double bonds gives optically active amino acids. The synthesis of these compounds mostly involves the oxidation of Oxidation of oxazolones or β-elimination of β-position functionalized amino acids, the reaction of imidoester 1 with aryl aldehyde 2 in sodium ethoxide-ethanol was studied: