目的　抗药性有两类 ,即获得性抗药性和固有性抗药性。对获得性抗药性已进行了广泛和深入的研究 ,并已证明了几条机制 ,而就我们所知 ,固有性抗药性的机制尚未被阐明。本文旨在探讨骨肉瘤细胞的获得性抗药性与固有性抗药性在细胞学和生物化学方面的差别。方法　将预选分离好的 Objective There are two types of drug resistance, namely acquired drug resistance and intrinsic drug resistance. Extensive and in-depth research has been conducted on acquired drug resistance, and several mechanisms have been demonstrated, and as far as we know, the mechanism of innate resistance has not yet been elucidated. This article aims to explore the differences in the cytological and biochemical aspects of acquired drug resistance and intrinsic resistance of osteosarcoma cells. Method will be pre-selected and separated