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目的:观察采用马来酸依那普利叶酸片对H型高血压患者进行治疗的临床效果。方法:于2011年2月至2016年3月中山市神湾医院就诊治疗的H型高血压患者150例,按入院时间均分为治疗组与对照组各75例。对照组给予马来酸依那普利进行治疗,观察组则给予马来酸依那普利叶酸片进行治疗。分析比较两组患者血压、血浆同型半胱氨酸(Hcy),颈动脉内膜中层厚度(IMT)改善情况。结果:治疗组治疗后收缩压(SBP)、舒张压(DBP)改善情况与对照组比较差,异具有统计学意义(P<0.05),与治疗前组内比较改善明显(P<0.01);对照组治疗后SBP改善情况与治疗前组内比较改善明显(P<0.01)。治疗组治疗后Hcy、IMT改善情况均优于治疗前(P<0.01),与对照组治疗后比较均改善明显(P<0.01)。结论:马来酸依那普利叶酸片治疗H型高血压效果显著,可明显改善患者的血压、血浆Hcy及IMT。
Objective: To observe the clinical effect of enalapril maleate folic acid tablets in patients with Hypertension. Methods: From Feb. 2011 to Mar. 2016, 150 cases of H-type hypertension treated in Shenwan Hospital of Zhongshan City were divided into treatment group and control group with 75 cases in each hospital. The control group was treated with enalapril maleate, while the observation group was treated with enalapril maleate folic acid tablets. Analysis of two groups of patients with blood pressure, plasma homocysteine (Hcy), carotid artery intima-media thickness (IMT) to improve the situation. Results: After treatment, SBP and DBP in treatment group were lower than those in control group (P <0.05), and were significantly improved compared with those before treatment (P <0.01). The improvement of SBP after treatment in the control group was significantly improved compared with that before treatment (P <0.01). The improvement of Hcy and IMT in the treatment group were better than those before treatment (P <0.01), and were significantly improved compared with the control group after treatment (P <0.01). Conclusion: The effect of enalapril maleate folate in treating Hypertension is significant, which can significantly improve the patients’ blood pressure, plasma Hcy and IMT.