糖尿病已经成为一种患病率呈逐年上升的由遗传和环境多因素相互作用引起的一组代谢紊乱综合症。,其慢性并发症常可累及全身各个系统 ,严重影响患者生活质量甚至致死致残。随着 1994年瘦素的发现[1 ] ,糖尿病的研究取得了重大的进展 ,诸多的研究发现瘦素及其受体与胰岛素抵抗及? Diabetes mellitus has become a group of metabolic syndrome with a rising prevalence of multiple genetic and environmental factors. , Its chronic complications can often affect the whole body of the system, seriously affecting the quality of life of patients and even cause death and disability. With the discovery of leptin in 1994 [1], significant progress has been made in the study of diabetes. Many studies have found that leptin and its receptors are associated with insulin resistance and insulin resistance.