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To the editor: Hepatitis C virus (HCV) is a hepatotropic virus and a common cause of chronic hepatitis.Several extrahepatic complications have been associated with HCV including autoimmune and kidney diseases.It can cause a variety of extrahepatic immunological manifestations.1 Chronic HCV infection and cirrhosis are risk factors of a variety of extrahepatic diseases such as mixed cryoglobulinemia and membranoproliferative glomerulonephritis (MPGN).2 We presented a cirrhosis patient with mixed cryoglobulinemia (MC) associated with HCV; the diagnosis was made by renal biopsy and improved completely after interferon (IFN) and ribavirin treatment.