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目的综述元素硅在先导化合物优化中的应用及其特点,从而为新药设计提供理论依据。方法对近年来国内外发表的文献进行归纳、总结。结果与结论对现有药物或候选药物进行碳/硅交换是一种寻求新化学实体的有效方法。
Objective To summarize the application of elemental silicon in the optimization of lead compounds and its characteristics, so as to provide a theoretical basis for the design of new drugs. Methods To summarize and summarize the published literatures at home and abroad in recent years. RESULTS AND CONCLUSIONS Carbon / silicon exchange of existing drugs or drug candidates is an effective way to seek new chemical entities.