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目的:探讨益肾I方对抗大鼠佐剂性关节炎大鼠模型TNF-α、IL-2的实验研究。方法:采用大鼠足跖注射Freund i’s完全佐剂形成佐剂性关节炎(AA),观察益肾I方对病鼠超敏反应与炎症左右足跖厚度,血清肿瘤坏死因子(TNF-α),白细胞介素-2(IL-2)和循环免疫复合物(C IC)的含量变化。结果:与模型组比较,注射佐剂的大鼠右后跖从第2d开始肿胀,持续15d(原发性损害),益肾I方可抑制大鼠足跖肿胀的程度,并能抑制TNF-,αIL-2、C IC和PGE2的释放从而发挥抗炎作用。结论:益肾I方及尼美舒利具有抗佐剂性关节炎(AA)和降低致炎因子和相关炎症介质的作用。
Objective: To investigate the effect of Yishen I prescription on TNF-α and IL-2 in rats with adjuvant arthritis. METHODS: Adjuvant arthritis (AA) was induced by injection of Freund i’s complete adjuvant into the rat’s athlete’s foot. The hypersensitivity and the thickness of the right and left paw of the kidney were observed. The serum tumor necrosis factor (TNF-α) was measured. Changes in the levels of IL-2 (IL-2) and circulating immune complexes (CIC). RESULTS: Compared with the model group, rats injected with adjuvant showed swelling of the right posterior fornix for 15 days (primary lesion) from the 2nd day. Yishen I can inhibit the swelling of the paw in rats and inhibit TNF- The release of αIL-2, CIC and PGE2 thus exerts anti-inflammatory effects. Conclusion: Yishen I and Nimesulide have anti-adjuvant arthritis (AA) and reduce the effect of pro-inflammatory factors and related inflammatory mediators.