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目的：探讨＜35岁孕妇孕中期血清学筛查唐氏综合征（(Down syndrome，DS)）风险值与不良妊娠结局发生的关系，评价D S筛查风险值对不良妊娠结局的预测价值。方法：选择2014年1月到2014年12月在我们产前筛查门诊进行孕中期血清学筛查DS高风险、中风险、低风险预产期年龄＜35周岁单胎妊娠孕妇各562例，观察三组孕妇发生妊娠合并贫血、妊娠期高血压疾病、妊娠期糖尿病、胎盘异常、羊水过少等内容；观察三组围产儿发生早产儿、胎儿宫内发育迟缓、胎儿宫内窘迫、新生儿室息、围产儿死亡等内容。结果：DS筛查高风险孕妇与中风险孕妇发生妊娠期高血压疾病、羊水过少、胎儿宫内窘迫间比较差异有统计学意义（P＜0.05）；D S筛查高风险孕妇与低风险孕妇发生妊娠合并贫血、妊娠期高血压疾病、妊娠期糖尿病、胎盘异常、羊水过少、胎儿宫内窘迫、新生儿室息间比较差异有统计学意义（P＜0.01，P＜0.05）；D S筛查中风险孕妇与低风险孕妇发生胎盘异常、新生儿室息间比较差异有统计学意义（P＜0.05）。结论：＜35岁孕妇孕中期血清学筛查D S风险值与不良妊娠结局发生的关系密切，如能加强对DS筛查高风险、中风险孕妇及其围产儿的监测和管理，可降低不良妊娠结局的发生。“,”Objective : To investigate the relationship between Down syndrome (DS) risk value and the occurrence of adverse pregnancy outcomes in the second trimester of pregnant women aged < 35 via serum screening and evaluate the predictive value of adverse pregnancy outcomes via DS screening risk value.Methods: Select separatively 562 cases of high-risk, medium-risk and low-risk second-trimester singleton pregnant women aged <35 via DS serum screening in our prenatal screening clinic from January 2014 to December 2014 and observe gestational anemia, gestational hypertension, gestational diabetes, placental abnormalities, oligohydramnios, etc. of the three groups of pregnant women and also observe perinatal preterm children, intrauterine growth retardation, fetal distress, neonatal asphyxia, perinatal death of the three groups.Results: Statistically significant (P<0.05) are the differences between high-risk pregnant women and medium-risk pregnant women with gestational hypertension, oligohydramnios and fetal distress via serum screening, the differences between high-risk pregnant women and low-risk pregnant women with gestational anemia, gestational hypertension, gestational diabetes, placental abnormalities, oligohydramnios, fetal distress and perinatal death via serum screening (P<0.01,P <0.05) and the differences between medium-risk pregnant women and low-risk pregnant women with placental abnormalities and perinatal death via serum screening (P<0.05).Conclusion: <35-year-old second-trimester pregnant women’s DS risk value via serum screening is closely related to the occurrence of adverse pregnancy outcomes.If we can strengthen the monitoring and management of DS serum screening of high-risk pregnant women, medium-risk pregnant women and perinatal children, the incidence of adverse pregnancy outcomes can be reduced.