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目的 :探讨急性低氧暴露对人体红细胞免疫功能及其免疫调节因子的影响。方法 :受试对象为北京体育大学体育系男子足球专项运动员 8名 ,平均年龄 2 0 .6 3± 0 .74岁。让受试者晚上在低氧房暴露 (居住 ) 10小时。低氧房空气中氧含量为 15 .3% (相当于海拨 2 5 0 0m)。分别于低氧暴露前 1天、急性低氧暴露 10小时后晨起取安静空腹静脉血测试 ,采用花环方法测定红细胞免疫功能、红细胞免疫促进因子和抑制因子活性。结果显示 ,急性低氧暴露 10小进后 ,机体RBC-C3bRR、RBC -ICRR急剧升高 (P <0 .0 1) ,同时出现免疫促进因子活性降低、免疫抑制因子活性升高的趋势。提示急性低氧应激后 ,红细胞免疫功能表现为亢进与紊乱 ,红细胞免疫调节系统对红细胞免疫功能亢进的反馈性调节作用可能发生障碍或作用较弱 ,机体红细胞免疫系统处于紊乱状态
Objective: To investigate the effects of acute hypoxic exposure on human erythrocyte immune function and immunoregulatory factors. Methods: Subjects were 8 male football special athletes from Beijing Sport University, with an average age of 20.63 ± 0.74 years. Subjects were exposed (lived) in hypoxic room for 10 hours at night. Low oxygen room air oxygen content of 15.3% (equivalent to 2500m above sea level). Respectively at 1 day before hypoxia exposure, 10 hours after acute hypoxia exposure to take quiet fasting venous blood test, the use of rosette determination of erythrocyte immune function, erythrocyte immune promoting factor and inhibitory factor activity. The results showed that RBC-C3bRR and RBC-ICRR increased sharply (P <0.01) after acute hypoxia exposure for 10 hours. Simultaneously, the activity of immunosuppressive factor decreased and the activity of immunosuppressive factor increased. Prompted acute hypoxic stress, erythrocyte immune function showed hyperthyroidism and disorder, erythrocyte immune regulatory system of red cell immune function hyperactivity feedback regulation may be impaired or weak, the body’s red blood cell immune system in a disorder