美《科学》第212卷17期(1981年)第314页报道:有效的男性节育药棉酚显然是抑制了在精子和精子发生细胞中有氧和无氧代谢中起关键性作用的一种酶。美国北卡罗来纳州的国立环境卫生科学研究所的李济育(译音)和马林(Heinrich V Malling)证明,棉酚的靶细胞酚是乳酸脱氢酶X。他们提供了关于该制剂作用机制的初步线索。这一发现是有前途的,因为它指出了棉酚既不影响性激素水平,也不影响 U.S. Science 212, 17 (1981), p. 314 reported that effective male sterility gossypol is clearly an enzyme that inhibits the crucial role of aerobic and anaerobic metabolism in sperm and spermatogenic cells . Li Jiyu and Heinrich V Malling of the National Institute of Environmental Health Sciences in North Carolina, USA, demonstrated that the target cell phenol of gossypol is lactate dehydrogenase X. They provided preliminary clues as to the mechanism of action of this agent. This finding is promising because it indicates that gossypol does not affect sex hormone levels nor affect