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目的和方法：本实验采用微电极细胞外记录，在３２只新西兰兔下丘脑视前区（ＰＯＡＨ）记录温敏神经元单位放电，观察电刺激腹中膈区（ＶＳＡ）对致热原ＩＬ－１β作用下兔ＰＯＡＨ温敏神经元放电的影响。结果：（ｌ）侧脑室注射白介素－１β（ＩＬ－１β）能使ＰＯＡＨ热敏神经元放电减少，冷敏神经元放电增加；而侧脑室注射人工脑脊液（ＡＣＳＦ）对热敏神经元和冷敏神经元的放电均无明显影响。（２）电刺激ＶＳＡ可反转ＩＬ－１β对ＰＯＡＨ热敏神经元和冷敏神经元的上述作用。结论：ＶＳＡ可能作为负调节中枢参与致热原作用下的体温调节。
PURPOSE AND METHODS: In this study, we used microelectrode extracellular recording to record the unit discharge of thermo-sensitive neurons in the hypothalamic preoptic area (POAH) of 32 New Zealand rabbits. To observe the effects of electrical stimulation of VSA on pyrogen- Effect of 1β on the discharge of POAH thermosensitive neurons in rabbits. Results: (1) Intracerebroventricular injection of interleukin-1β (IL-1β) decreased the discharge of POAH thermosensitive neurons and increased the discharge of cold-sensitized neurons. However, intracerebroventricular injection of artificial cerebrospinal fluid (ACSF) Neuronal discharge had no significant effect. (2) Electrical stimulation of VSA reverses the above effects of IL-1β on POAH thermosensitive neurons and cold-sensitive neurons. Conclusion: VSA may be involved in the regulation of thermoregulation as a negative regulator of thermoregulation.